@article{JXYM3898,
author = {Ba Hamadou and Jérôme Boombhi and Leaticia A. Yowo and Sylvie Ndongo Amougou and Alain Menanga and Samuel Kingue},
title = {Aetiologies and correlates of secondary mitral regurgitation in patients with dilated cardiopathy in Cameroon: a cross-sectional study},
journal = {Journal of Xiangya Medicine},
volume = {2},
number = {4},
year = {2017},
keywords = {},
abstract = {Background: Dilated cardiopathy is a heterogeneous group of heart disease in which there is progressive ventricular remodeling, with or without secondary functional mitral regurgitation (MR). MR has prognostic implications, and has not been studied in our setting. This work aimed at studying the occurrence, aetiologies and correlates of secondary MR in a group of patients with dilated cardiopathy in a resource limited setting in sub-Saharan Africa.
Methods: We carried out a cross-sectional study in the echocardiography laboratories of three tertiary hospitals in the city of Yaounde, Cameroon. Participants were consecutively recruited over an eight month period, after results of echocardiograms. The severity of MR was assessed from the size of the regurgitant orifice and the mechanism of MR assessed with the Carpentier classification.
Results: A total of 25 participants (13 males) with an echocardiographic dilated left ventricle were included in the study. Their mean age was 53.2 years (range: 22 to 84 years). All patients had MR, of whom 6 (24%) had severe MR (grade IV). Type I MR was seen in 14 (46%), type III in 10 (40%), and type I and III in 1 (4%) of patients. The baseline heart disease were primary 4 (16%), ischemic 10 (40%), hypertensive 10 (40%), and peri-partum cardiomyopathy. The left atrium was dilated in 22 (88%), raised filling pressure in 19 (76%), and raised pulmonary pressure in 15 (60%). The severity of MR significantly correlated with age (r=0.5, P=0.011), left ventricle end diastolic diameter (r=0.41, P=0.04), low ejection fraction (r=−0.378, P=0.031), and left atrial size (r=0.431, P=0.022).
Conclusions: Secondary MR is almost always present in patients with dilated cardiopathy. The severity of MR correlated with age, low ejection fraction, left ventricular end diastolic diameter, and left atrial size.},
issn = {2519-9390}, url = {https://jxym.amegroups.org/article/view/3898}
}