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Global microRNA downregulation: all roads lead to estrogen

   
@article{JXYM4049,
	author = {Amit Cohen and Mario Alberto Burgos-Aceves and Yoav Smith},
	title = {Global microRNA downregulation: all roads lead to estrogen},
	journal = {Journal of Xiangya Medicine},
	volume = {2},
	number = {7},
	year = {2017},
	keywords = {},
	abstract = {MicroRNAs (miRNAs) are small noncoding segments of RNA, that negatively regulate gene expression at the post-transcriptional level and fine-tune gene functions. A widespread repression in miRNA expression was observed in different types of human tumors, and after exposure to cigarette-smoke, or to the hormone estrogen. The association of miRNAs downregulation in cancer, and after estrogen treatment, with guanine (Gua) enrichment in the terminal loop sequences of their precursors, suggests a possible link between estrogen-related miRNA-Gua adducts formation and carcinogenesis.},
	issn = {2519-9390},	url = {https://jxym.amegroups.org/article/view/4049}
}