%0 Journal Article
%T Global microRNA downregulation: all roads lead to estrogen
%A Cohen, Amit
%A Burgos-Aceves, Mario Alberto
%A Smith, Yoav
%J Journal of Xiangya Medicine
%D 2017
%B 2017
%9 
%! Global microRNA downregulation: all roads lead to estrogen
%K 
%X MicroRNAs (miRNAs) are small noncoding segments of RNA, that negatively regulate gene expression at the post-transcriptional level and fine-tune gene functions. A widespread repression in miRNA expression was observed in different types of human tumors, and after exposure to cigarette-smoke, or to the hormone estrogen. The association of miRNAs downregulation in cancer, and after estrogen treatment, with guanine (Gua) enrichment in the terminal loop sequences of their precursors, suggests a possible link between estrogen-related miRNA-Gua adducts formation and carcinogenesis.
%U https://jxym.amegroups.org/article/view/4049
%V 2
%P 
%@ 2519-9390