TY  - JOUR
AU  - Cohen, Amit
AU  - Burgos-Aceves, Mario Alberto
AU  - Smith, Yoav
PY  - 2017
TI  - Global microRNA downregulation: all roads lead to estrogen
JF  - Journal of Xiangya Medicine; Vol 2 (July 2017): Journal of Xiangya Medicine
Y2  - 2017
KW  - 
N2  - MicroRNAs (miRNAs) are small noncoding segments of RNA, that negatively regulate gene expression at the post-transcriptional level and fine-tune gene functions. A widespread repression in miRNA expression was observed in different types of human tumors, and after exposure to cigarette-smoke, or to the hormone estrogen. The association of miRNAs downregulation in cancer, and after estrogen treatment, with guanine (Gua) enrichment in the terminal loop sequences of their precursors, suggests a possible link between estrogen-related miRNA-Gua adducts formation and carcinogenesis.
UR  - https://jxym.amegroups.org/article/view/4049