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NPR1 inhibitors: new drugs for itch treatment?

   
@article{JXYM5548,
	author = {Liang Cao and Lixia Du and Hongzhen Hu},
	title = {NPR1 inhibitors: new drugs for itch treatment?},
	journal = {Journal of Xiangya Medicine},
	volume = {4},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {In this issue of Science Translational Medicine, Solinski et al. (2019) (1) reported that pharmacological blockade of natriuretic peptide receptor 1 (NPR1), a receptor of neuropeptide natriuretic polypeptide b (NPPB), expressed by a subpopulation of mouse and human spinal cord neurons, may be the key to alleviate chronic itching. Further, the authors have identified small-molecule human NPR1 antagonists which could suppress chronic itch in mice without inducing significant adverse side effects.},
	issn = {2519-9390},	url = {https://jxym.amegroups.org/article/view/5548}
}