Individualized multidisciplinary treatment options for hepatocellular carcinoma in the department of liver surgery: experiences in Xiangya Hospital of Central South University

Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Genomic and morphological heterogeneity has been well identified in HCC. The overall survival (OS) of HCC patients after hepatic resection (HR) is heterogeneous. The histology-based definition of the morphological heterogeneity of HCC has been modified and refined to treat patients with targeted therapies, but this still cannot solve all the problems. In addition, recent advances in genomic medicine have enhanced the understanding of genetic and epigenetic events occurring in HCC, raising the possibility of personalizing targeted agents in accordance with the genetic make-up of the tumors. In this review article, we aim to give a summary of the recent the development of individualized multidisciplinary treatment for HCC.